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COPY SUBMITTED IN IDS 



INTERNATIONAL SEARCH REPORT 



International application No. 

PCT/JP2 006/3 11625 



A. CLASSIFICATION OF SUBJECT MATTER 
A61K47/26 (2006 .01) i, A61K9/19 ( 2 006 



01) i, A61K39/3 95 (200 6 . 01) i 



According to International Patent Classification (IPC) or to both national classification and IPC 
B. FIELDS SEARCHED 

Minim um documentation searched (classification system followed by classification symbols) 

A61K47/26 (2006 . 01) i, A61K9/19 (2 006 . 01 ) i , A61K39/395 (2 00 6 . 0 1 ) i 



Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched 
Jitsuyo Shinan Koho 1922-1996 Jitsuyo Shinan Toroku Koho 1996-2006 

Kokai Jitsuyo Shinan Koho 1971-2006 Toroku Jitsuyo Shinan Koho 1994-2006 



Electronic data base consulted during the international search (name of data base and, where practicable, search terms used) 
CA(STN) , MEDLINE (STN) 



C. DOCUMENTS CONSIDERED TO BE RELEVANT 



Category* 



Citation of document, with indication, where appropriate, of the relevant passages 



JP 3-41033 A (Kyowa Hakko Kogyo Co., Ltd.), 

21 February, 1991 (21.02.91), 

Full text; particularly, Claim 4 

& WO 91/00739 A & EP 437622 A 

JP 2004-292455 A (Chugai Pharmaceutical Co., 
Ltd. ) , 

21 October, 2004 (21.10.04), 
Full text 

& WO 2003/068260 A 
& US 2005/214278 A 



Relevant to claim No. 



X 

y 



1-2, 5-10, 

13-17 
3-4 , 11-12, 
18-21 

3-4 , 11-12, 
18-21 



& EP 1475101 A 



WO 93/06862 A (Toray Industries, Inc.), 

15 April, 1993 (15.04.93), 

Full text 

& EP 562125 A 



3-4 , 11-12, 
18-21 



I x I Further documents are listed in the continuation of Box C. 1 I See patent family annex. 



* Special categories of cited documents: 

"A" document defining the general state of the art which is not considered to 
be of particular relevance 

^E" earlier application or patent but published on or after the international filing 
date 

"L" document which may throw doubts on priority claim(s) or which is 
cited to establish the publication date of another citation or other 
special reason (as specified) 
"O" document referring to an oral disclosure, use, exhibition or other means 
"P" document published prior to the international filing date but later than the 
priority date claimed 



•Y" 



later document published after the international filing date or priority 
date and not in conflict with the application but cited to understand 
the principle or theory underlying the invention 

document of particular relevance; the claimed invention cannot be 
considered novel or cannot be considered to involve an inventive 
step when the document is taken alone 

document of particular relevance; the claimed invention cannot be 
considered to involve an inventive step when the document is 
combined with one or more other such documents, such combination 
being obvious to a person skilled in the art 

document member of the same patent family 



Date of the actual completion of the international search 
09 August, 2006 (09.08.06) 


Date of mailing of the international search report 
22 August, 2006 (22.08.06) 


Name and mailing address of the ISA 

Japanese Patent Office 

Facsimile No. 


Authorized officer 
Telephone No. 



Form PCTTSA/210 (second sheet.) (April 2005) 



COPY SUBMITTED IN IDS 



INTERNATIONAL SEARCH REPORT 



International application No. 

PCT/JP2006/3 11625 



C (Continuation). DOCUMENTS CONSIDERED TO BE RELEVANT 



Category* 



Citation of document, with indication, where appropriate, of the relevant passages 



Relevant to claim No. 



WO 2 004-0372 93 A (Dainippon Sumitomo Seiyaku 

Kabushiki Kaisha) , 

06 May, 2004 (06.05.04), 

Full text 

& EP 1559433 A & US 2005/267222 A 

WO 2003/086324 A (Alios Therapeutics, Inc.), 
23 October, 2003 (23.10.03), 
Full text 

&. US 2003/232887 A & EP 1496863 A 

& JP 2005-532288 A 

WO 98/22136 A (Roche Diagnostics GmbH) , 
28 May, 1998 (28.05.98), 
Full text 

& EP 852951 A & EP 941121 B 

& JP 2001-503781 A 



15-17 



15 



1-21 



Form PCT/ISA/210 (continuation of second sheet) (April 2005)